Many translated example sentences containing “leucémie aigue myéloïde” – English-French dictionary and search engine for English translations. Les patients atteints de leucémie aiguë myéloïde (LAM) peuvent développer une insuffisance respiratoire aiguë (IRA) dès les premiers jours de. Request PDF on ResearchGate | On Jan 1, , S Hdiji Mseddi and others published Leucemie aigue myeloide de novo a chromosome philadelphie positif.
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Here we review the current indications of SCT in this disease. Top of the page – Article Outline. Acute myeloid leukemia AML is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation.
You can move this window by clicking on the headline. Disease definition Acute myeloid leukemia AML is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation.
While data supporting progenitor cells committed to specific myeloid cell type has been reported, other studies argue in favor for a more immature stem. Differential diagnosis includes megaloblastic anaemia, myelodysplastic syndromes, acute lymphoblastic leukemia, acute biphenotypic leukemia, chronic myeloid leukemia myeloid blast phaseand metastases of tumors such rhabdomyosarcoma and neuroblastoma see these terms.
Some drugs such as azacitidine or decitabine are available for the treatment of elderly AML patients under specific circumstances. Health care resources for this disease Expert myeloidf Diagnostic tests Patient organisations 44 Orphan drug s The documents contained in this web site are presented for information purposes only.
Diagnosis relies on laboratory findings showing anemia, thrombocytopenia and leucopenia or leukocytosis which result from disturbed hematopoietic function due to bone marrow and peripheral blood infiltration by immature blast cells.
Differential diagnosis Differential diagnosis includes megaloblastic anaemia, myelodysplastic syndromes, acute lymphoblastic leukemia, acute biphenotypic leukemia, chronic myeloid leukemia myeloid blast phaseand metastases of tumors such rhabdomyosarcoma and neuroblastoma see these terms.
Extramedullary accumulation of myeloid blasts in different tissues, mainly skin, can be observed and is known as myeloid sarcoma see this term.
Only comments written in English can be processed. Additional information Further ajgue on this disease Classification s 2 Gene s 34 Other website s 2. Access to the text HTML. Pathogenesis of Lecuemie is still unclear but a two-hit model has been suggested as the probable mechanism for leukemogenesis.
Leucémie myéloïde aiguë
Allogeneic stem cell transplantation SCT is an increasingly important therapeutic option for the treatment of adult patients with acute myeloid leukemia.
Clinical description Although, AML can occur at any age, myelodie is typically a disease affecting elder people, usually more than 65 years. Central nervous system infiltration is uncommon and mainly related with monocytic variants.
Check this box if you wish to receive a copy ymeloide your message. Personal information regarding our website’s visitors, including their identity, is confidential. Specialised Social Services Eurordis directory. Diagnosis of AML also relies on bone marrow aspirate or biopsy after the disease has been suspected. Class I mutations resulting in proliferative advantage while the class II mutations alter the normal hematopoietic differentiation. Although it is presumed to be a curative strategy, major complications of SCT remain graft-versus-host disease, delayed immune recovery, multiple comorbidities, and relapse after lejcemie.
Detailed information Article for general public Deutsch Current indications of allogeneic stem cell transplant in adults with acute myeloid leukemia.
Leucémie aiguë promyélocytaire
Based on stratification, patients can be treated with chemotherapy consolidation or allogenic hematopoietic stem cell transplantation HSCT. Refractory or relapsed AML is treated with a second induction course adding new drugs such gemtuzumab ozogamicin to the standard treatment.
Diagnostic methods Diagnosis relies on laboratory findings showing anemia, thrombocytopenia and leucopenia or leukocytosis which result from disturbed hematopoietic function due to bone marrow and peripheral blood infiltration by immature blast cells.
That means that AML could be the consequence of at least 2 different types of gene mutations. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Although, AML can occur at any age, it is typically a disease affecting elder people, usually more than 65 years.
Summary and related texts.
Patients with intermediate prognoses should also receive SCT in first complete remission. Etiology Leucfmie of AML is still unclear but a two-hit model has been suggested as the probable mechanism for leukemogenesis. Access to the PDF text.
Prognosis Prognosis varies widely according aiguue cytogenetics, molecular findings, response to induction treatment and age, between others. For all other comments, please send your remarks via contact us.
As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your ajgue data.
Journal page Archives Contents list. Despite major differences among transplant centers in the intensity and composition of the conditioning regimen and immunosuppression, choice of graft source, postgraft immune-modulation, and supportive care, there has been a dramatic improvement in terms of tolerance.
Controversy is also still in the type of cell from which AML arises.
You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. The main clinical picture consists of a short time period with pallor, fatigue, fever, infections and hemorrhages.
If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. After morphological examination, immunophenotyping of leukemic cells, cytogenetic and molecular analysis should be performed.
Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Testes are usually not affected. Prognosis varies widely according to cytogenetics, molecular findings, response to induction treatment and age, between others. Prognosis of elder patients is rather poor.
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All of them are characterized by clonal expansion of myeloid blasts.