HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Studies have shown [ citation needed ] that the evolutionary fate of minisatellites hypervariiable towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability.

Sign In Forgot password? Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. You must accept the terms and conditions.

This article has multiple issues. Please check for further notifications by email. Retrieved from ” https: Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements.

Minisatellite

Dynamic evolution of megasatellites in yeasts. Oxford University Press is a department of the University of Oxford. Learn how and when to remove these template messages.

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You have entered an invalid code. The first human minisatellite was discovered in by A. This article is also available for rental through DeepDyve. The human telomere sequence itself is a tandem repeat: Please help us clarify the article.

Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite profiling in the s. Thank you for submitting a comment on this article. If you originally registered with a username please use that to sign in. Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower than in sperm.

Add comment Close comment form modal. Sequences flanking the repeat arrays of human minlsatellites: We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element huan have a cis-acting function.

Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena. Studies have revealed distinct mutation processes operating in somatic and germline cells. There might be a discussion about this on the talk page. This article needs hyoervariable from an expert in Genetics.

Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs.

Please help improve it or discuss these issues on the talk page. A novel human nonviral retroposon derived from an endogenous retrovirus.

Minisatellite – Wikipedia

Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion minisatellits of variant repeats along the array, which provides details on the structure of the alleles before and after mutation.

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This article is about the DNA sequence. From Wikipedia, the free encyclopedia. Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that ih at this class of tandem repeat.

Minisatellites have been implicated [ citation needed ] as regulators of gene expression e.

Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar

Finally, with the discovery of tandem iterations of simple hypervariablr motifs, the term microsatellites was coined. Related articles in Web of Science Google Scholar. We present DNA sequences flanking cloned hypervariable human minisatellites. Your comment will be reviewed and published at the journal’s discretion. H-NS uses an autoinhibitory conformational humxn for environment-controlled gene silencing.

Receive exclusive offers and updates from Oxford Academic. You do not currently have access to this article. In contrast, complex inter-allelic conversion-like events occur in the germline. Minisatellites have been associated hypervarizble chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints.

It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. For the size class of orbiting spacecraft, see miniaturized satellite. Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes.